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Article

A common IL‐4 receptor variant promotes asthma severity via a Treg cell GRB2‐IL‐6‐Notch4 circuit

16 Jul 2022

Abstract excerpt

Abstract Background The mechanisms by which genetic and environmental factors interact to promote asthma remain unclear. Both the IL‐4 receptor alpha chain R576 (IL‐4RαR576) variant and Notch4 license asthmatic lung inflammation by allergens and ambient pollutant particles by subverting lung regulatory T (Treg) cells in an IL‐6‐dependent manner. Objective We examined the interaction between IL‐4RαR576 and Notch4...

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Identifiers

PMID: 35841382
DOI: 10.1111/all.15444

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