Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice.

Journal of human genetics - 1 Nov 2009

Kulawiec Mariola, Owens Kjerstin M, Singh Keshav K

Abstract excerpt

We investigated the effect of the mitochondrial DNA (mtDNA) polymorphism G10398A found in African-American women with aggressive breast cancer on apoptosis and tumorigenesis. We generated human cytoplasmic hybrid (cybrid) by repopulation of recipient rho(0) cells (devoid of mtDNA) with donor mtDNA derived from patients with breast cancer harboring the G10398A polymorphism. We investigated a number of functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport Complex I
Share to Hybrid Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

Share to Membrane Potential, Mitochondrial

Share to Mice, SCID

Share to Proto-Oncogene Proteins c-akt

Share to Reactive Oxygen Species

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 19763141
DOI: 10.1038/jhg.2009.89
PMCID: PMC2909846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice.PMID 19763141Read ↗

Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women.Semantic proximity Read ↗

Diminished tumorigenic phenotype after depletion of mitochondrial DNA.Semantic proximity Read ↗

Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis.Semantic proximity Read ↗

Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women.Semantic proximity Read ↗

Mitochondrial DNA mutations regulate metastasis of human breast cancer cells.Semantic proximity Read ↗

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.Semantic proximity Read ↗

Peripheral blood mitochondrial DNA content, A10398G polymorphism, and risk of breast cancer in a Han Chinese population.Semantic proximity Read ↗

Prognostic value of mitochondrial DNA content and G10398A polymorphism in non-small cell lung cancerSemantic proximity Read ↗

Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation.Semantic proximity Read ↗

Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis.Semantic proximity Read ↗

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.Semantic proximity Read ↗

Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.