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Article

Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation.

International journal of cancer - 1 May 2018

Ma Lin, Fu Qingzi, Xu Bing, Zhou Huaibin, Gao Jing, Shao Xiaoli, Xiong Jingting, Gu Qianru, Wen Shumeng, Li Fengjie, Shen Lijun, Chen Guorong, Fang Hezhi, Lyu Jianxin

Abstract excerpt

In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial technology, we demonstrate that the D5 haplogroup is associated with an increased risk of breast cancer...

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PMID: 29226320
DOI: 10.1002/ijc.31207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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