Article
Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women.
Cancer genetics and cytogenetics - 1 Feb 2008
Setiawan Veronica Wendy, Chu Li-Hao, John Esther M, Ding Yuan Chun, Ingles Sue A, Bernstein Leslie, Press Michael F, Ursin Giske, Haiman Christopher A, Neuhausen Susan L
Abstract excerpt
Mitochondria play important roles in cellular energy production, free radical generation, and apoptosis. In a previous report, the mitochondrial DNA (mtDNA) G10398A (Thr-->Ala) polymorphism was associated with breast cancer risk in African-American women [Cancer Res 2005;65:8028-33]. We sought to replicate the association by genotyping the G10398A polymorphism in multiple established population-based case-control...
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