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Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis.

Annals of the New York Academy of Sciences - 1 Apr 2004

Liu Chun-Yi, Lee Cheng-Feng, Hong Chiung-Hui, Wei Yau-Huei

Abstract excerpt

Mitochondrial diseases, such as MELAS, MERRF, and CPEO syndromes, are associated with specific point mutations or large-scale deletions of mitochondrial DNA (mtDNA), which impair mitochondrial respiratory functions and result in decreased production of ATP in affected tissues. Recently, mitochondria have been recognized to act as key players in the regulation of cell death. To investigate whether a pathogenic...

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PMID: 15126291
DOI: 10.1007/978-3-662-41088-2_14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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