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Article

Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis.

Journal of neurochemistry - 1 Jul 2004

Carrozzo Rosalba, Rizza Teresa, Stringaro Annarita, Pierini Roberta, Mormone Elisabetta, Santorelli Filippo M, Malorni Walter, Matarrese Paola

Abstract excerpt

The key role of mitochondria in the apoptotic process is well understood, but not many data are available regarding the specific role of mitochondrial DNA mutations in determining cell fate. We investigated whether two mitochondrial DNA mutations (L217R and L156R) associated with maternally-inherited Leigh syndrome may play a specific role in triggering the apoptotic cascade. Considering that different nuclear...

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PMID: 15228605
DOI: 10.1111/j.1471-4159.2004.02505.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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