Lung cancer and the debrisoquine metabolic phenotype.

doi:10.1093/jnci/82.15.1264

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Article

Lung cancer and the debrisoquine metabolic phenotype.

Journal of the National Cancer Institute - 1 Aug 1990

Caporaso N E, Tucker M A, Hoover R N, Hayes R B, Pickle L W, Issaq H J, Muschik G M, Green-Gallo L, Buivys D, Aisner S

Abstract excerpt

In a case-control study, we tested the hypothesis that the genetically determined ability to metabolize debrisoquine is related to risk of lung cancer. Overall, individuals who were extensive metabolizers of debrisoquine were at significantly greater risk of lung cancer than those who were poor o...

Topics

Adenocarcinoma
Case-Control Studies
Debrisoquin
Female
Humans
Isoquinolines
Lung Diseases, Obstructive
Lung Neoplasms
Male
Middle Aged
Phenotype
Risk
Risk Factors
Smoking

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