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Article

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

14 Sept 2009

Abstract excerpt

Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus production are central to the pathogenesis of chronic pulmonary diseases. However, little is known about the transcriptional programs that regulate goblet cell differentiation. Here, we show that SAM-pointed domain-containing Ets-like factor...

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PMID: 19759516
DOI: 10.1172/jci39731

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