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Article

SPDEF regulates goblet cell hyperplasia in the airway epithelium.

The Journal of clinical investigation - 1 Apr 2007

Park Kwon-Sik, Korfhagen Thomas R, Bruno Michael D, Kitzmiller Joseph A, Wan Huajing, Wert Susan E, Khurana Hershey Gurjit K, Chen Gang, Whitsett Jeffrey A

Abstract excerpt

Goblet cell hyperplasia and mucous hypersecretion contribute to the pathogenesis of chronic pulmonary diseases including cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In the present work, mouse SAM pointed domain-containing ETS transcription factor (SPDEF) mRNA and protein w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17347682
DOI: 10.1172/JCI29176
PMCID: PMC1810569

Genes

SPDEF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17347682-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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SPDEF regulates goblet cell hyperplasia in the airway epithelium.PMID 17347682Read ↗

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus productionSemantic proximity Read ↗

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Runx2, a novel regulator for goblet cell differentiation and asthma developmentSemantic proximity Read ↗

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Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

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Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2Semantic proximity Read ↗

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