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Article

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

24 Apr 2017

Abstract excerpt

Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) regulate goblet cell differentiation. This study aimed to (1) investigate DNA methylation and expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28450970
DOI: 10.1186/s13148-017-0341-7

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