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Article

Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.

The American journal of pathology - 1 Jul 2013

Marko Christina K, Menon Balaraj B, Chen Gang, Whitsett Jeffrey A, Clevers Hans, Gipson Ilene K

Abstract excerpt

Goblet cell numbers decrease within the conjunctival epithelium in drying and cicatrizing ocular surface diseases. Factors regulating goblet cell differentiation in conjunctival epithelium are unknown. Recent data indicate that the transcription factor SAM-pointed domain epithelial-specific transcription factor (Spdef) is essential for goblet cell differentiation in tracheobronchial and gastrointestinal...

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Identifiers

PMID: 23665202
DOI: 10.1016/j.ajpath.2013.03.017
PMCID: PMC3702735

Genes

SPDEF

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