Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Runx2, a novel regulator for goblet cell differentiation and asthma development

17 Oct 2016

Abstract excerpt

Airway goblet cell differentiation and related mucus overproduction are critical processes in the development of respiratory diseases, including asthma. The underlying mechanisms, however, are not fully understood. We identified Runt-related transcription factor 2 (Runx2) as a novel regulator for goblet cell differentiation. Runx2 was up-regulated by 6.4-fold during IL-13-induced goblet cell differentiation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Neonatal Respiratory Health Research
Share to Pediatric health and respiratory diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27825108
DOI: 10.1096/fj.201600954r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Runx2, a novel regulator for goblet cell differentiation and asthma developmentPMID 27825108Read ↗

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus productionSemantic proximity Read ↗

SPDEF regulates goblet cell hyperplasia in the airway epithelium.Semantic proximity Read ↗

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPDSemantic proximity Read ↗

The Roles of RUNX Family Proteins in Development of Immune Cells.Semantic proximity Read ↗

Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasisSemantic proximity Read ↗

Foxa2 Programs Th2 Cell-Mediated Innate Immunity in the Developing LungSemantic proximity Read ↗

Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthmaSemantic proximity Read ↗

Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial CellsSemantic proximity Read ↗

Airway Epithelial Transcription Factor NK2 Homeobox 1 Inhibits Mucous Cell Metaplasia and Th2 InflammationSemantic proximity Read ↗

RUNX1: A Regulator of NF-κB Signaling in Pulmonary DiseasesSemantic proximity Read ↗

MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 ExpressionSemantic proximity Read ↗

METTL3 mediates SOX5 m6A methylation in bronchial epithelial cells to attenuate Th2 cell differentiation in T2 asthmaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.