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Article

MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model

18 Jan 2022

Abstract excerpt

BACKGROUND: Airway mucus hypersecretion is one of the important pathological features of chronic obstructive pulmonary disease (COPD). MUC5B is the main mucin expressed in the airways of COPD patients and has been indicated to play an important role in airway defense. However, the specific biological function of MUC5B in COPD and the possible mechanism are not clear. METHODS: mice exposed to cigarette smoke and...

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PMID: 35042537
DOI: 10.1186/s12931-021-01920-8

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