Article

Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells

2020-07-09

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death in the United States and is primarily caused by cigarette smoking. Increased numbers of mucus-producing secretory (“goblet”) cells defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to COPD pathophysiology. The objective of this study was to determine whether NOTCH signaling regulates goblet cell differen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30865dd2-7dda-5aa9-8073-19f041ea3797
DOI: 10.1101/2020.07.09.195818

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial CellsDOI 10.1101/2020.07.09.195818Read

Transcriptional Regulation of Airway Epithelial Cell Differentiation: Insights into the Notch Pathway and BeyondSemantic proximity Read

Electronic Cigarette Aerosol Exposure Induces Airway Remodeling in 3D Human Tracheobronchial Epithelial Tissues: From Goblet Cell Hyperplasia to Squamous MetaplasiaSemantic proximity Read

Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory PathwaySemantic proximity Read

Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolutionSemantic proximity Read

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus productionSemantic proximity Read

Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung diseaseSemantic proximity Read

Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells.Semantic proximity Read

Cigarette Smoke Specifically Affects Small Airway Epithelial Cell Populations and Triggers the Expansion of Inflammatory and Squamous Differentiation Associated Basal CellsSemantic proximity Read

SPDEF regulates goblet cell hyperplasia in the airway epithelium.Semantic proximity Read

Single-cell RNA sequencing reveals heterogeneity of ALI model and epithelial cell alterations after exposure to electronic cigarette aerosolSemantic proximity Read

Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cellsSemantic proximity Read

JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway EpitheliumSemantic proximity Read