Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus.

Journal of autoimmunity - 1 Jun 2010

Lin Qingshun, Hou Rong, Sato Aya, Ohtsuji Mareki, Ohtsuji Naomi, Nishikawa Keiko, Tsurui Hiromichi, Amano Hirofumi, Amano Eri, Sudo Katsuko, Nishimura Hiroyuki, Shirai Toshikazu, Hirose Sachiko

Abstract excerpt

The autoimmune-type Fcgr2b with deletion polymorphism in AP-4-binding site in the promoter region is suggested to be one most plausible susceptibility gene for systemic lupus erythematosus (SLE). We previously found that there is a strong epistatic interaction between the autoimmune-type Fcgr2b polymorphism and Y chromosome-linked autoimmune acceleration (Yaa) mutation, thus severe SLE observed in BXSB males...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Receptors, Fc

Share to Receptors, IgG

Source

Identifiers

PMID: 19758787
DOI: 10.1016/j.jaut.2009.08.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus.PMID 19758787Read ↗

Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background.Semantic proximity Read ↗

The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.Semantic proximity Read ↗

Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses.Semantic proximity Read ↗

Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus.Semantic proximity Read ↗

Lessons from BXSB and related mouse models.Semantic proximity Read ↗

B-cell activating factor promoter polymorphisms in egyptian patients with systemic lupus erythematosus.Semantic proximity Read ↗

FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease.Semantic proximity Read ↗

Significance of MHC class II haplotypes and IgG Fc receptors in SLE.Semantic proximity Read ↗

The Complex Association of FcγRIIb With Autoimmune Susceptibility.Semantic proximity Read ↗

Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus.Semantic proximity Read ↗

Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.Semantic proximity Read ↗

Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.