Article
Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2002
Xiu Yan, Nakamura Kazuhiro, Abe Masaaki, Li Na, Wen Xiang Shu, Jiang Yi, Zhang Danqing, Tsurui Hiromichi, Matsuoka Shuji, Hamano Yoshitomo, Fujii Hiroyuki, Ono Masao, Takai Toshiyuki, Shimokawa Toshibumi, Ra Chisei, Shirai Toshikazu, Hirose Sachiko
Abstract excerpt
FcgammaRIIB1 molecules serve as negative feedback regulator for B cell Ag receptor-elicited activation of B cells; thus, any impaired FcgammaRIIB1 function may possibly be related to aberrant B cell activation. We earlier found deletion polymorphism in the Fcgr2b promoter region among mouse strains in which systemic autoimmune disease-prone NZB, BXSB, MRL, and autoimmune diabetes-prone nonobese diabetic, but not...
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