Article
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2011
Boross Peter, Arandhara Victoria L, Martin-Ramirez Javier, Santiago-Raber Marie-Laure, Carlucci Francesco, Flierman Roelof, van der Kaa Jos, Breukel Cor, Claassens Jill W C, Camps Marcel, Lubberts Erik, Salvatori Daniela, Rastaldi Maria Pia, Ossendorp Ferry, Daha Mohamed R, Cook H Terence, Izui Shozo, Botto Marina, Verbeek J Sjef
Abstract excerpt
FcγRIIB-deficient mice generated in 129 background (FcγRIIB(129)(-/-)) if back-crossed into C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in mice and humans, the Fcγr2b gene is located within a genomic interval on chromosome 1 associated with lupus susceptibility. In mice, the 129-derived haplotype of this interval, named Sle16, causes loss of self-tolerance in the context of...
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