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Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia.

Carcinogenesis - 1 May 2008

Liu Chen-yu, Hsu Yi-Hsiang, Pan Pi-Chen, Wu Ming-Tsang, Ho Chi-Kung, Su Li, Xu Xin, Li Yi, Christiani David C

Abstract excerpt

The aldo-keto reductase 1C3 (AKR1C3) gene located on chromosome 10p15-p14, a regulator of myeloid cell proliferation and differentiation, represents an important candidate gene for studying human carcinogenesis. In a prospectively enrolled population-based case-control study of Han Chinese conducted in Kaohsiung in southern Taiwan, a total of 114 leukemia cases and 221 controls <20 years old were recruited...

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Identifiers

PMID: 18339682
DOI: 10.1093/carcin/bgn071
PMCID: PMC2902386

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