Article

Loss of a subunit of vacuolar ATPase identifies unexpected biological signatures of reduced organelle acidification <i>in vivo</i>

2020-11-30

Abstract excerpt

The inability to maintain a strictly regulated endo(lyso)somal acidic pH through the proton-pumping action of the vacuolar-ATPases has been associated with various human diseases including heritable connective tissue disorders, neurodegenerative diseases and cancer. Multiple studies have investigated the pleiotropic effects of reduced acidification in vitro , but the mechanisms elicited by impaired endo(lyso)soma...

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Literature Corpus work: 218e5dcc-476f-5948-ba94-dadc3b6ec88a
DOI: 10.1101/2020.11.30.397463

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