Article
Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease.
PLoS computational biology - 1 Apr 2015
Flynn William F, Chang Max W, Tan Zhiqiang, Oliveira Glenn, Yuan Jinyun, Okulicz Jason F, Torbett Bruce E, Levy Ronald M
Abstract excerpt
While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapies containing protease inhibitors (PIs). Due to the high sequence coverage within each sample, the frequencies of...
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