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Article

Synthetic lethals in HIV: ways to avoid drug resistance : Running title: Preventing HIV resistance.

Biology direct - 17 Apr 2015

Petitjean Michel, Badel Anne, Veitia Reiner A, Vanet Anne

Abstract excerpt

BACKGROUND: RNA viruses rapidly accumulate genetic variation, which can give rise to synthetic lethal (SL) and deleterious (SD) mutations. Synthetic lethal mutations (non-lethal when alone but lethal when combined in one genome) have been studied to develop cancer therapies. This principle can also be used against fast-evolving RNA-viruses. Indeed, targeting protein sites involved in SD + SL interactions with a...

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Identifiers

PMID: 25888435
DOI: 10.1186/s13062-015-0044-y
PMCID: PMC4399722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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