Article
Differential patterns of HOX gene expression are associated with specific integrin and ICAM profiles in clonal populations isolated from a single human melanoma metastasis.
International journal of cancer - 29 May 1996
Cillo C, Cantile M, Mortarini R, Barba P, Parmiani G, Anichini A
Abstract excerpt
Homeobox-containing genes comprise a gene family coding for transcription factors involved in normal development. Class I human homeobox (HOX) genes display a peculiar chromosomal organization, perhaps directly related to their function. Aberrant expression of homeobox genes has been associated with both morphological abnormalities and oncogenesis. We have reported that HOX gene expression is (i) specific for...
Topics
- Adult
- Clone Cells
- Gene Expression Regulation, Neoplastic
- Genes, Homeobox
- Humans
- Integrins
- Intercellular Adhesion Molecule-1
- Melanoma
- Phenotype
- Sensitivity and Specificity