Adhesion of tumour-infiltrating lymphocytes to endothelium: a phenotypic and functional analysis.

doi:10.1038/bjc.1997.245

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Article

Adhesion of tumour-infiltrating lymphocytes to endothelium: a phenotypic and functional analysis.

British journal of cancer - 1 Jan 1997

Adams D H, Yannelli J R, Newman W, Lawley T, Ades E, Rosenberg S A, Shaw S

Abstract excerpt

Efficacy of cancer immunotherapy with cultured tumour-infiltrating lymphocytes (TILs) depends upon infused TILs migrating into tumour-bearing tissue, in which they mediate an anti-tumour response. For TILs to enter a tumour, they must first bind to tumour endothelium, and this process depends on...

Topics

Cell Adhesion
Cell Adhesion Molecules
Cells, Cultured
Endothelium, Vascular
Humans
Integrins
Lymphocyte Activation
Lymphocytes, Tumor-Infiltrating
Phenotype
T-Lymphocytes

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