Article
Adhesion of tumour-infiltrating lymphocytes to endothelium: a phenotypic and functional analysis.
British journal of cancer - 1 Jan 1997
Adams D H, Yannelli J R, Newman W, Lawley T, Ades E, Rosenberg S A, Shaw S
Abstract excerpt
Efficacy of cancer immunotherapy with cultured tumour-infiltrating lymphocytes (TILs) depends upon infused TILs migrating into tumour-bearing tissue, in which they mediate an anti-tumour response. For TILs to enter a tumour, they must first bind to tumour endothelium, and this process depends on TILs expressing and regulating the function of relevant cell-surface receptors. We analysed the cell-surface phenotype...
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