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Article

Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect.

Environmental health perspectives - 1 Sept 2009

Imboden Medea, Schwartz Joel, Schindler Christian, Curjuric Ivan, Berger Wolfgang, Liu Sally L J, Russi Erich W, Ackermann-Liebrich Ursula, Rochat Thierry, Probst-Hensch Nicole M

Abstract excerpt

BACKGROUND: Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution. OBJECTIVE:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19750108
DOI: 10.1289/ehp.0800430
PMCID: PMC2737020

Genes

CCND1

Variants

rs9344
rs9344
rs9344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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