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Article

HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction.

The European respiratory journal - 1 Mar 2010

Curjuric I, Imboden M, Schindler C, Downs S H, Hersberger M, Liu S L J, Matyas G, Russi E W, Schwartz J, Thun G A, Postma D S, Rochat T, Probst-Hensch N M

Abstract excerpt

Reduced exposure to particulate matter with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)) attenuated age-related lung function decline in our cohort, particularly in the small airways. We hypothesised that polymorphisms in glutathione S-transferase (GST) and haem oxygenase-1 (HMOX1) genes, important for oxidative stress defence, modify these beneficial effects. A population-based sample of 4,365 adults...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20190330
DOI: 10.1183/09031936.00044309

Genes

HMOX1
GSTP1
GSTM1
GSTT1

Variants

rs2071746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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