Article
Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis.
Environmental health perspectives - 1 Jan 2015
Imboden Medea, Kumar Ashish, Curjuric Ivan, Adam Martin, Thun Gian Andri, Haun Margot, Tsai Ming-Yi, Pons Marco, Bettschart Robert, Turk Alexander, Rochat Thierry, Künzli Nino, Schindler Christian, Kronenberg Florian, Probst-Hensch Nicole M
Abstract excerpt
BACKGROUND: Both air pollution and genetic variation have been shown to affect lung function. Their interaction has not been studied on a genome-wide scale to date. OBJECTIVES: We aimed to identify, in an agnostic fashion, genes that modify the association between long-term air pollution exposure and annual lung function decline in an adult population-based sample. METHODS: A two-stage genome-wide interaction...
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