Article
Genome-wide association study of lung function decline in adults with and without asthma.
The Journal of allergy and clinical immunology - 1 May 2012
Imboden Medea, Bouzigon Emmanuelle, Curjuric Ivan, Ramasamy Adaikalavan, Kumar Ashish, Hancock Dana B, Wilk Jemma B, Vonk Judith M, Thun Gian A, Siroux Valerie, Nadif Rachel, Monier Florent, Gonzalez Juan R, Wjst Matthias, Heinrich Joachim, Loehr Laura R, Franceschini Nora, North Kari E, Altmüller Janine, Koppelman Gerard H, Guerra Stefano, Kronenberg Florian, Lathrop Mark, Moffatt Miriam F, O'Connor George T, Strachan David P, Postma Dirkje S, London Stephanie J, Schindler Christian, Kogevinas Manolis, Kauffmann Francine, Jarvis Debbie L, Demenais Florence, Probst-Hensch Nicole M
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified determinants of chronic obstructive pulmonary disease, asthma, and lung function level; however, none have addressed decline in lung function. OBJECTIVE: We conducted the first genome-wide association study on the age-related decrease in FEV(1) and its ratio to forced vital capacity (FVC) stratified a priori by asthma status. METHODS: Discovery cohorts...
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