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Article

Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease.

American journal of respiratory cell and molecular biology - 1 Mar 2011

Foreman Marilyn G, Kong Xiangyang, DeMeo Dawn L, Pillai Sreekumar G, Hersh Craig P, Bakke Per, Gulsvik Amund, Lomas David A, Litonjua Augusto A, Shapiro Steven D, Tal-Singer Ruth, Silverman Edwin K

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is characterized by alveolar destruction and abnormal inflammatory responses to noxious stimuli. Surfactant protein-D (SFTPD) is immunomodulatory and essential to host defense. We hypothesized that polymorphisms in SFTPD could influence the susceptibility to COPD. We genotyped six single-nucleotide polymorphisms (SNPs) in surfactant protein D in 389 patients with COPD...

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Source

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Identifiers

PMID: 20448057
DOI: 10.1165/rcmb.2009-0360OC
PMCID: PMC3095932

Genes

SFTPD
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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