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Article

Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population.

PloS one - 1 Jan 2012

Curjuric Ivan, Imboden Medea, Nadif Rachel, Kumar Ashish, Schindler Christian, Haun Margot, Kronenberg Florian, Künzli Nino, Phuleria Harish, Postma Dirkje S, Russi Erich W, Rochat Thierry, Demenais Florence, Probst-Hensch Nicole M

Abstract excerpt

BACKGROUND: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes. OBJECTIVES: We studied the interaction of both exposures with a broad set of oxidative-stress related candidate genes and pathways on lung function decline and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22792237
DOI: 10.1371/journal.pone.0040175
PMCID: PMC3391223

Genes

FEV
CRISP2
MAF
SNCA

Provenance

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