Studies of protein-protein interactions in Fanconi anemia pathway to unravel the DNA interstrand crosslink repair mechanism.

doi:10.1016/j.ijbiomac.2017.05.166

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Studies of protein-protein interactions in Fanconi anemia pathway to unravel the DNA interstrand crosslink repair mechanism.

International journal of biological macromolecules - 1 Nov 2017

Siddiqui Mohd Quadir, Rajpurohit Yogendra S, Thapa Pankaj S, Maurya Ganesh Kumar, Banerjee Kuheli, Khan Mudassar Ali, Panda Pragnya, Hasan Syed K, Gadewal Nikhil, Misra Hari S, Varma Ashok K

Abstract excerpt

Fanconi anemia (FA), a cancer predisposition syndrome exhibits hallmark feature of radial chromosome formation, and hypersensitivity to DNA crosslinking agents. A set of FA pathway proteins mainly FANCI, FANCD2 and BRCA2 are expressed to repair the covalent crosslink between the dsDNA. However, FA, BRCA pathways play an important role in DNA ICL repair as well as in homologous recombination repair, but the...

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Studies of protein-protein interactions in Fanconi anemia pathway to unravel the DNA interstrand crosslink repair mechanism.

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