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Article

A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys.

Drug and alcohol dependence - 1 Jun 2010

Vallender Eric J, Rüedi-Bettschen Daniela, Miller Gregory M, Platt Donna M

Abstract excerpt

BACKGROUND: Variation at the human mu-opioid receptor has been associated with alcohol abuse. The A118G (N40D) polymorphism in humans is functionally mimicked by the C77G (P26R) polymorphism in rhesus monkeys; both show similar in vitro influences on ligand binding and in vivo correlations with physiological measures as well as behavioral measures including predilection towards alcohol consumption. Naltrexone, an...

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Source

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Identifiers

PMID: 20153935
DOI: 10.1016/j.drugalcdep.2010.01.005
PMCID: PMC2875311

Genes

OPRM1

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