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Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway

14 Sept 2009

Abstract excerpt

Mesothelin, a secreted protein, is overexpressed in some cancers, but its exact function remains unclear. The aim of the present study was to evaluate the possible function of mesothelin. Real-time PCR, RT (reverse transcription)-PCR, cytotoxicity assays, proliferative assays, apoptotic assays by Hoechst staining, detection of active caspases 3 and 7 by flow cytometric analysis, and immunoprecipitation and...

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PMID: 19747165
DOI: 10.1042/bj20082196

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