Article
Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma.
Oncotarget - 18 Apr 2017
Inaguma Shingo, Wang Zengfeng, Lasota Jerzy, Onda Masanori, Czapiewski Piotr, Langfort Renata, Rys Janusz, Szpor Joanna, Waloszczyk Piotr, Okoń Krzysztof, Biernat Wojciech, Ikeda Hiroshi, Schrump David S, Hassan Raffit, Pastan Ira, Miettinen Markku
Abstract excerpt
Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in several types of malignant tumors sometimes in association with increased tumor aggressiveness and poor clinical outcome. In the present study, 1562 tumors were immunohistochemically analyzed for mesothelin expression using two different types of mouse monoclonal antibodies (5B2 and MN-1) to determine the...
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