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Mesothelin

15 Jun 2004

Abstract excerpt

Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The mesothelin gene encodes a precursor protein that is processed to yield the 40-kDa protein, mesothelin, attached to the cell membrane by a glycosylphosphatidyl inositol linkage and a 31-kDa shed fragment named...

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PMID: 15217923
DOI: 10.1158/1078-0432.ccr-03-0801

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