Article
Podoplanin overexpression in human mesothelioma cell lines enhances the tumorigenic phenotype.
Oncology reports - 1 Mar 2013
Yamaki Ei, Yajima Toshiki, Kosaka Takayuki, Mogi Akira, Tanaka Shigebumi, Kuwano Hiroyuki
Abstract excerpt
Podoplanin, a small type I integral membrane mucin-type sialoglycoprotein, serves as a useful marker for diagnosing malignant pleural mesothelioma (MPM); however, the physiological function of podoplanin in mesothelioma cells is not known. To elucidate the role of podoplanin in the pathogenesis of MPM, we generated two mesothelioma cell lines (PODO1 and PODO2) that...
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