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Article

Mesothelin regulates growth and apoptosis in pancreatic cancer cells through p53-dependent and -independent signal pathway.

Journal of experimental & clinical cancer research : CR - 3 Oct 2012

Zheng Chunning, Jia Wei, Tang Yong, Zhao HuiLiang, Jiang Yingsheng, Sun Shaochuan

Abstract excerpt

Mesothelin, a secreted protein, is overexpressed in some cancers, including pancreatic cancer. Rescent studies have shown that overexpression of mesothelin significantly increased tumor cell proliferation, and downregulation of mesothelin inhibited cell proliferation in pancreatic cancer cells, but its exact function and mechanism remains unclear. The aim of the present study was to evaluate the effects of...

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Identifiers

PMID: 23034174
DOI: 10.1186/1756-9966-31-84
PMCID: PMC3585882

Genes

MIA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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