Article
Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells.
Molecular cancer - 14 Mar 2017
He Xiaoqing, Wang Liying, Riedel Heimo, Wang Kai, Yang Yong, Dinu Cerasela Zoica, Rojanasakul Yon
Abstract excerpt
BACKGROUND: Lung cancer and pleural mesothelioma are two of the most deadly forms of cancer. The prognosis of lung cancer and mesothelioma is extremely poor due to limited treatment modalities and lack of understanding of the disease mechanisms. We have identified mesothelin as a potentially unique therapeutic target that as a specific advantage appears nonessential in most cell types. Mesothelin (MSLN), a plasma...
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