Article

SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

2024-01-26

Abstract excerpt

Resistance to chemotherapy and PARPi inhibitors remains a critical challenge in the treatment of epithelial ovarian cancer, mainly due to disabled apoptotic responses in tumor cells. Given mesothelin’s pivotal role in ovarian cancer and its restricted expression in healthy tissues, we conducted a drug-screening discovery analysis across a range of genetically modified cancer cells to unveil mesothelin’s therapeuti...

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Identifiers and source

Literature Corpus work: a487e444-c262-57b3-b3f8-dc9053182ff6
DOI: 10.1101/2024.01.24.576987

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