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Article

High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis.

Oncotarget - 10 May 2015

Thomas Anish, Chen Yuanbin, Steinberg Seth M, Luo Ji, Pack Svetlana, Raffeld Mark, Abdullaev Zied, Alewine Christine, Rajan Arun, Giaccone Giuseppe, Pastan Ira, Miettinen Markku, Hassan Raffit

Abstract excerpt

Mesothelin is a cell surface glycoprotein which is highly expressed in several epithelial cancers and may have a role in cell adhesion and metastases. In this study, we used prospectively obtained clinical and pathological data to characterize mesothelin expression in advanced lung adenocarcinoma. Tissue was obtained from patients who underwent molecular profiling of potentially actionable genes on a trial of...

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Identifiers

PMID: 26028668
DOI: 10.18632/oncotarget.3429
PMCID: PMC4484487

Genes

KRAS
EGFR
AKT1
ALK
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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