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Article

VKORC1 diplotype-derived dosing model to explain variability in warfarin dose requirements in Asian patients.

Drug metabolism and pharmacokinetics - 1 Jan 2009

Sandanaraj Edwin, Lal Suman, Cheung Yin Bun, Xiang Xiaoqiang, Kong Ming Chai, Lee Lai Heng, Ooi London Lucien, Chowbay Balram

Abstract excerpt

SUMMARY: Warfarin-induced bleeding complications and high inter-patient variability are major hindrances to oral anticoagulant therapy. The present study identifies the influence of VKORC1 diplotypes, CYP2C9 and CYP2C19 variants on warfarin disposition and dose requirements in Chinese patients (n...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19745563
DOI: 10.2133/dmpk.24.365

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19745563-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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