Article
Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2006
Pojoga Luminita, Kolatkar Nikheel S, Williams Jonathan S, Perlstein Todd S, Jeunemaitre Xavier, Brown Nancy J, Hopkins Paul N, Raby Benjamin A, Williams Gordon H
Abstract excerpt
Two genetic variants of the beta-2 adrenergic receptor, 46G>A and 79C>G, affect agonist-mediated receptor downregulation and vascular reactivity. We determined whether these variants were associated with hypertension, per se, blood pressure response to dietary sodium, 2 forms of salt-sensitive hypertension (low renin and nonmodulation), and the activity of the renin-angiotensin-aldosterone system. Included are...
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