Article
G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.
American journal of hypertension - 1 Mar 2009
Bhatnagar Vibha, O'Connor Daniel T, Brophy Victoria H, Schork Nicholas J, Richard Erin, Salem Rany M, Nievergelt Caroline M, Bakris George L, Middleton John P, Norris Keith C, Wright Jackson, Hiremath Leena, Contreras Gabriel, Appel Lawrence J, Lipkowitz Michael S
Abstract excerpt
BACKGROUND: African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis. METHODS: Participants from...
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