Article
Multiple restriction fragment length polymorphisms at the GLUT2 locus: GLUT2 haplotypes for genetic analysis of type 2 (non-insulin-dependent) diabetes mellitus.
Diabetologia - 1 Nov 1991
Patel P, Bell G I, Cook J T, Turner R C, Wainscoat J S
Abstract excerpt
The liver/islet glucose transporter (GLUT2) is expressed in the liver and in the Beta cells of pancreatic islets and is a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus. A series of restriction fragment length polymorphisms have been identified using a GLUT2 cDNA probe with five restriction enzymes in a British white Caucasian population. Five independent restriction...
Topics
- Alleles
- DNA Probes
- Deoxyribonuclease EcoRI
- Deoxyribonucleases, Type II Site-Specific
- Diabetes Mellitus, Type 2
- Gene Frequency
- Genetic Linkage
- Haplotypes
- Humans
- Islets of Langerhans
