Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin-dependent) diabetes mellitus in a British Caucasian population.

doi:10.1007/BF00399959

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Article

Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin-dependent) diabetes mellitus in a British Caucasian population.

Diabetologia - 1 Mar 1993

Cavan D A, Jacobs K H, Penny M A, Kelly M A, Mijovic C, Jenkins D, Fletcher J A, Barnett A H

Abstract excerpt

Inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus is partly determined by HLA genes. It has been suggested that protection from disease may be conferred by HLA-DQB1 genes which encode molecules with aspartate at position 57. We investigated the contributions of HLA-DRB1, DQ...

Topics

Adult
Alleles
Amino Acid Sequence
Base Sequence
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Histocompatibility Antigens Class II
Humans
Immunity, Innate

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Histocompatibility Complex

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8462775
DOI: 10.1007/BF00399959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8462775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.