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Article

Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitus.

Diabetologia - 1 Feb 1991

Jenkins D, Mijovic C, Jacobs K H, Penny M A, Fletcher J, Barnett A H

Abstract excerpt

Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabetic and control subjects of North Indian origin supported the DQw1.18 allele of the DQB1 gene as a determinant of...

Topics

Alleles
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
England
Gene Frequency
Genetic Predisposition to Disease
HLA-DQ Antigens
India
Major Histocompatibility Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Nucleic Acid Hybridization

Oligonucleotide Probes

Source

Identifiers

PMID: 2065845
DOI: 10.1007/BF00500381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2065845-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitus.PMID 2065845Read ↗

Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping.Semantic proximity Read ↗

HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population.Semantic proximity Read ↗

An investigation of Japanese subjects maps susceptibility to type 1 (insulin-dependent) diabetes mellitus close to the DQA1 gene.Semantic proximity Read ↗

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.Semantic proximity Read ↗

Analysis of HLA genotypes and susceptibility to insulin-dependent diabetes mellitus: association maps telomeric to HLA-DP.Semantic proximity Read ↗

Cross-ethnic group comparisons of HLA class II alleles and insulin dependent diabetes mellitus.Semantic proximity Read ↗

Both DQA1 and DQB1 genes are implicated in HLA-associated protection from type 1 (insulin-dependent) diabetes mellitus in a British Caucasian population.Semantic proximity Read ↗

Similarity of HLA-DQ profiles in adult-onset type 1 insulin-dependent diabetic patients with and without extra-pancreatic auto-immune disease.Semantic proximity Read ↗

Analysis of HLA genotypes and susceptibility to insulin-dependent diabetes mellitus: HLA-DQ alpha complements HLA-DQ beta.Semantic proximity Read ↗

Genes for insulin-dependent diabetes mellitus (IDDM) in the major histocompatibility complex (MHC) of African-Americans.Semantic proximity Read ↗

HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.Semantic proximity Read ↗

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