Article
Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology.
Pharmacogenetics and genomics - 1 Oct 2009
Kraggerud Sigrid M, Oldenburg Jan, Alnaes Grethe I, Berg Marianne, Kristensen Vessela N, Fossa Sophie D, Lothe Ragnhild A
Abstract excerpt
PURPOSE: The pathogenesis of testicular germ cell tumor (TGCT) remains unknown. The aim of this study was to evaluate the pathogenic role of functional polymorphisms in detoxification enzymes among TGCT patients, through association studies of constitutive genotypes and medical parameters before and after chemotherapy. EXPERIMENTAL DESIGN: Germline deletion polymorphisms in the glutathione S-transferase mu 1...
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