Article
Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma.
Cancer genetics and cytogenetics - 1 Apr 2010
Cho Hyun-Jung, Eom Hyeon-Seok, Kim Hyun-Ju, Kim In-Suk, Lee Gyeong Won, Kong Sun-Young
Abstract excerpt
Polymorphisms in detoxification enzymes of the glutathione S-transferase (GST) family are associated with treatment response, resistance, and drug-related toxicity, all of which affect final clinical outcome. In this study, we investigated the influence of the genetic polymorphisms GSTM1, GSTT1, and GSTP1 on treatment response in 94 Korean patients with de novo diffuse large B-cell lymphoma, who had received...
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