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Article

Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2007

Oldenburg Jan, Kraggerud Sigrid M, Cvancarova Milada, Lothe Ragnhild A, Fossa Sophie D

Abstract excerpt

PURPOSE: Cisplatin, a cornerstone of combination chemotherapy in the treatment of testicular cancer, induces hearing impairment with considerable interindividual variations. These differences might be a result of functional polymorphisms in cisplatin-detoxifying enzymes like glutathione S-transferases (GSTs). PATIENTS AND METHODS: We identified 173 cisplatin-treated testicular cancer survivors (TCSs) who had...

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Source

Identifiers

PMID: 17228018
DOI: 10.1200/JCO.2006.08.9599

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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