Article
Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Sept 2022
Grasso Chiara, Popovic Maja, Isaevska Elena, Lazzarato Fulvio, Fiano Valentina, Zugna Daniela, Pluta John, Weathers Benita, D'Andrea Kurt, Almstrup Kristian, Anson-Cartwright Lynn, Bishop D Timothy, Chanock Stephen J, Chen Chu, Cortessis Victoria K, Dalgaard Marlene D, Daneshmand Siamak, Ferlin Alberto, Foresta Carlo, Frone Megan N, Gamulin Marija, Gietema Jourik A, Greene Mark H, Grotmol Tom, Hamilton Robert J, Haugen Trine B, Hauser Russ, Karlsson Robert, Kiemeney Lambertus A, Lessel Davor, Lista Patrizia, Lothe Ragnhild A, Loveday Chey, Meijer Coby, Nead Kevin T, Nsengimana Jérémie, Skotheim Rolf I, Turnbull Clare, Vaughn David J, Wiklund Fredrik, Zheng Tongzhang, Zitella Andrea, Schwartz Stephen M, McGlynn Katherine A, Kanetsky Peter A, Nathanson Katherine L, Richiardi Lorenzo
Abstract excerpt
BACKGROUND: Testicular germ cell tumors (TGCT), histologically classified as seminomas and nonseminomas, are believed to arise from primordial gonocytes, with the maturation process blocked when they are subjected to DNA methylation reprogramming. SNPs in DNA methylation machinery and folate-dependent one-carbon metabolism genes have been postulated to influence the proper establishment of DNA methylation....
Read the complete abstract on PubMed