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Article

Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome.

International journal of clinical oncology - 1 Jun 2003

Medeiros Rui, Pereira Deolinda, Afonso Noémia, Palmeira Carlos, Faleiro Cristina, Afonso-Lopes Carlos, Freitas-Silva Margarida, Vasconcelos André, Costa Sandra, Osório Teresa, Lopes Carlos

Abstract excerpt

BACKGROUND: The glutathione S-transferases (GSTs) are a group of multifunctional enzymes that catalyze the conjugation of glutathione with a variety of electrophilic compounds, including cytotoxic agents. A significant percentage of normal individuals exhibit genetic polymorphism with a homozygous deletion (null genotype) of the genes, leading to absence of the enzyme. METHODS: In the present study we analyzed...

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Source

Identifiers

PMID: 12851839
DOI: 10.1007/s10147-003-0318-8

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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